Pentraxin-3: an acute phase protein as a biomarker
DOI:
https://doi.org/10.5281/zenodo.15324040Keywords:
Acute phase protein, Inflammation, Cytokine, Immune responseAbstract
Acute phase proteins are the substances that react the earliest with chemotactic excitations of cytokines in infectious conditions. They also play a role as an acute phase response as part of innate immunity. Acute phase proteins can be used as biomarkers of systemic inflammatory conditions caused by infection/inflammatory responses, regardless of the causative agent. It can also help in the early detection and prognosis of inflammatory responses. Pentraxin-3 is an acute phase protein belonging to the pentraxin family that plays an important role in the defense of living things against pathogens. It is a possible biomarker for the diagnosis and prognosis of infectious and non-infectious diseases, especially those associated with inflammatory processes, involved in cellular and humoral immune response. Its use Its use in both human and veterinary medicine is expanding.
References
Günaştı N, Balcı Ş, Tamer L. Pentraksinler. Mersin Üni¬versitesi Sağlık Bilimleri Dergisi, 2017; 10(1), 65-69. DOI: 10.26559/mersinsbd.324017
Arslanoğlu MÖ. Yenidoğan solunum sistemi hastalıklarında Pentraksin III (PTX3) düzeyleri. Tıpta uzamanlık tezi, Eskişehir Osmangazi Üniversitesi Sağlık Bilimleri Enstitü¬sü, 2021; Eskişehir. DOI: 10.13140/RG.2.2.12177.81764
Zlibut A, Bocsan IC, Agoston-Coldea L. Pentraxin-3 and endothelial dysfunction. Advances in Clinical Chemistry, 2019; 91, 163-179. DOI: 10.1016/bs.acc.2019.03.001
Taşçene N. Akut faz proteinlerinin hayvanlarda önemi. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 2017; 57(1), 52-60. DOI: 10.19159/lahaed.465416
Okutani D. The role of long pentraxin 3, a new inflamatory mediator in inflamatory responses. Japanese Journal of Clinical Immunology, 2006; 29(3), 107-113. DOI: 10.2177/jsci.29.107
Jie Ma Y, Garred P. Pentraxins in Complement Activation and Regulation. Frontiers in Immunology, 2018; 9, 1-6. DOI: 10.3389/fimmu.2018.03046
Öztelcan B. Preterm yenidoğanlarda umbilikal kord kanında inflamasyon parametrelerinin ve pentraksin III’ün (PTX3) değerlendirilmesi. Tıpta Uzmanlık Tezi, Eskişehir Osmangazi Üniversitesi Sağlık Bilimler Enstitüsü, 2010; Eskişehir. DOI: 10.13140/RG.2.2.12177.81764
Mantovani A, Garlanda C, Bottazzi B. Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. Vaccine, 2003; 21(2), 43-47. DOI: 10.1016/S0264-410X(02)00777-3
Basile A, Sica A, d’Aniello E, et al. Characterization of the promoter for the human long pentraxin PTX3. The Journal of Biological Chemistry, 1997; 272 (13), 8172–8178. DOI: 10.1074/jbc.272.13.8172
Norata GD, Garlanda C, Catapano AL. The Long Pentraxin PTX3: A Modulator of the Immunoinflammatory Respon¬se in atherosclerosis and cardiovascular diseases. Trends in Cardiovascular Medicine, 2010; 20(2), 35–40. DOI: 10.1016/j.tcm.2010.01.001
Ristagno G, Fumagalli F, Bottazzi B, et al. Pentraxin 3 in cardiovaskuler disease. Frontiers in Immunology, 2019; 10, 1-7. DOI: 10.3389/fimmu.2019.00023
Foo S, Reading PC, Jaillon S, Mantovani A, Suresh M. Pentraxins and collectins: Friend or foe during pathogen invasion. Trends in Microbiology, 2015; 23(12), 799-808. DOI: 10.1016/j.tim.2015.08.003
Bottazzi B, Vouret-Craviari V, Bastone A, et al. Multimer formation and ligand recognition by the long pentraxin PTX3. The Journal of Biological Chemistry, 1997; 272 (52), 32817–32823. DOI: 10.1074/jbc.272.52.32817
Inforzatoa A, Doni A, Barajona I, et al. PTX3 as a paradigm for the interaction of pentraxins with the complement system. Seminars in Immunology, 2013; 25 (1), 79–85. DOI: 10.1016/j.smim.2012.11.004
Mantovani A, Garlanda C, Doni A, Bottazzi B. Pentraxins in innate immunity: From C-Reactive protein to the long pentraxin PTX3. Journal of Clinical Immunology, 2008; 28, 1–13. DOI: 10.1007/s10875-007-9157-0
Deban L, Jarva H, Lehtinen MJ, et al. Binding of the long pentraxin PTX3 to Factor H: Interacting domains and function in the regulation of complement activation. The Journal of Immunology, 2008; 181 (12) 8433-8440. DOI: 10.4049/jimmunol.181.12.8433
Abderrahim-Ferkoune A, Bezy O, Chiellini C, et al. Characterization of the long pentraxin PTX3 as a TNF-induced secreted protein of adipose cells. Journal of Lipid Research, 2003; 44, 994-1000. DOI: [10.1194/jlr.M
Giacomini A, Ghedini GC, Presta M, Ronca R. Long pentraxin 3: A novelmultifaceted player in cancer. Biochimica et Biophysica Acta (BBA), 2018; 1869(1), 53–63. DOI: 10.1016/j.bbamcr.2017.10.004
Haapasalo K, Meri S. Regulation of the complement system by pentraxins. Frontiers in Immunology, 2019; 10, 1-9. DOI: 10.3389/fimmu.2019.01750
Aygün O, Yıldız R. Evaluation of thrombomodulin and pentraxin-3 as diagnostic biomarkers in calves with sepsis. Veterinarni Medicina, 2018; 63, 313–320. DOI: 10.17221/88/2017-VETMED
Reading PC, Bozza S, Gilbertson B, et al. Antiviral activity of the long chain pentraxin PTX3 againts Influenza Viruses. The Journal of Immunology, 2008; 180 (5), 3391- 3398. DOI: 10.4049/jimmunol.180.5.3391
Xu J, Mu Y, Zhang Y, et al. Antibacterial effect of porcine PTX3 against Streptococcus suis type 2 infection. Microbial Pathogenesis, 2015; 89, 128-139. DOI: 10.1016/j. micpath.2015.09.004
Inoue K, Kodama T, Daida H. Pentraxin 3: A novel biomarker for inflammatory cardiovascular disease. International Journal of Vascular Medicine, 2012; 1-6. DOI: 10.1155/2012/746071
Munshi UK, Niu JO, Siddiq MM, Parton LA. Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. Pediatric Pulmonology, 1997; 24(5), 331-36. DOI: 10.1002/(SICI)1099- 0496(199711)24:5<331::AID-PPUL3>3.0.CO;2-#
Peri G, Introna M, Corradi D, et al. PTX3, A prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans. Circulation, 2000; 102(6), 636-641. DOI: 10.1161/01.CIR.102.6.636
Szymkowiak M, Surmiak P, Baumert M. Pentraxin 3 – possible uses in neonatology and paediatrics. Pediatria & Medycyna Rodzinna, 2020; 16(3), 247–250. DOI: 10.15557/PiMR.2020.003
Suzuki S, Takeishi Y, Niizeki T, et al. Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure. American Heart Journal, 2008; 155 (1), 75-81. DOI: 10.1016/j. ahj.2007.08.017
Oliveira THC, Souza DG, Teixeria MM Amaral FA. Tissue dependent role of PTX3 during ischemia-reperfusion injury. Frontiers in Immunology, 2019; 10, 1-7. DOI: 10.3389/fimmu.2019.01750
Mauri T, Coppadoro A, Bellani G, et al. Pentraxin 3 in acute respiratory distress syndrome: An early marker of severity. Critical Care Medicine, 2008; 36(8), 2302-2307. DOI:10.1097/CCM.0b013e31817c8a3b
Nauta AJ, Haij S, Bottazzi B, et al. Human renal epithelial cells produce the long pentraxin PTX3. Kidney International, 2005; 67(2), 543–553. DOI numarası: 10.1111/j.1523-1755.2005.67111.x
Qiu C, Liu T, Luo D, Xie Z. Pentraxin 3: a powerful orchestrator in urinary tract infection. Nanotheranostics, 2021; 5(4), 445-447. DOI: 10.7150/ntno.60901
Sprong T, Peri G, Neeleman C, et al. Pentraxin 3 and C-Reactive Protein in Severe Meningococcal Disease. SHOCK, 2009; 31(1), 28-32. DOI: 10.1097/SHK. 0b013e31817fd543
Kalyon S, Gökden Y, Oyman F. A new biological marker in inflammatory bowel disease: Pentraxin 3. Journal of Surgery and Medicine, 2020; 4(10), 875-878. DOI:10.28982/ josam.791156
Bottazzi B, Inforzato A, Messa M, et al. The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling. Journal of Hepatology, 2016; 64, 1416-1427. DOI:10.1016/j.jhep.2016.02.029
Townsend M, Singh B. Pentraxin 3 expression in lungs and neutrophils of calves. Veterinary Immunology and Immunopathology, 2021; 236, 1-7. DOI:10.1016/j.vetimm.2021.110251
Wang J, Zhou X, Pan B, et al. Expression pattern of interferon-inducible transcriptional genes in neutrophils during bovine tuberculosis infection. DNA and Cell Biology, 2013; 32(8), 1-7.DOI: 10.1089/dna.2012.1941
Ramery E, Fıevez L, Fraıpont A, Bureau F, Lekeux P. Characterization of pentraxin 3 in the horse and its expression in airways. Veterinary Research, 2010; 4 (2), 1-10. PMID: 19863902
Jaillon S, Mancuso G, Hamon Y, et al. Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from pseudomonas aeruginosa lung infection. The Journal of Immunology, 2013; 191(4), 1873–1882. DOI:10.4049/jimmunol.1201642
Ganheim C, Alenıus S, Waller KP. Acute phase proteins as indicator of calf herd health. Vet J. 2007; 173: 645-51. DOI:10.1016/j.tvjl.2006.01.011
Townsend M, Singh B. Pentraxin 3 expression in lungs and neutrophils of calves. Veterinary Immunology and Immunopathology, 2021; 236, 110251. DOI:10.1016/j. vetimm.2021.110251
Akyüz E, Merhan O, Aydın U, et al. Pentraxin-3, endothelin-1, some biochemical parameters and hematology in bovine respiratory disease complex. Iranian Journal of Veterinary Research, 2023; 24(2), 143. doi: 10.22099/ IJVR.2023.46494.6674
Edwards TA. Control methods for bovine respiratory disease for feedlot cattle. Veterinary clinics: Food animal practice, 2010; 26(2), 273-284. DOI:10.1016/j. cvfa.2010.03.005.
Guterbock WM. The impact of BRD: the current dairy experience. Animal health research reviews, 2014 15(2), 130-134. DOI: 10.1017/S1466252314000140
Eroğlu M, Erdoğan HM. Serum pentraxin 3 levels in cats with feline parvovirus infection. Journal of Advances in VetBio Science and Techniques, 2023; 8(2), 150-158. https://doi.org/10.31797/vetbio.1321720
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Animal and Veterinary Journal

This work is licensed under a Creative Commons Attribution 4.0 International License.